Advances in Immunomodu lators for Vaccines to Prevent and Treat Autoimmune Diseases

Autoimmune disease across the world is spreading like an epidemic. The numbers are only increasing. According to a renowned autoimmune doctor in Pune, there is an increase in patients at an alarming rate with each passing day.

As each immune system differs, autoimmune disease treatment is becoming a challenging task. Autoimmunity is a condition where the immune system kills the bad cells along with the good ones while fighting infections. It is in no condition to differentiate a foe from a friend and in turn affecting joints, skin, gut, and brain cells.

With improved health conditions over the years, doctors involved in autoimmune disease treatment have noticed the spread of the disease globally and say it is not limited to the developed nations alone.

Researchers studying various epidemics have found a correlation in changing environmental factors and a rise in autoimmune diseases. As per autoimmune specialist in Pune, there are around 80 types of autoimmune diseases but the triggering reason and the cause is still unknown.

The current therapies and treatment suppress the cells causing the shift in the immune functions through medications. These medication side effects can have serious implications on the patient’s health. Autoimmune doctor in Pune believes there should be better ways of treatment than administering immunosuppressors. A need for less toxicity and long term treatments is the call of the hour.

Immunomodulators are used to regulate the immune system.  Autoimmune specialist in Pune points out that as the DNA, T-cell receptors, and T-cells play an important role in autoimmunity conditions, using various immunomodulators vaccinations help in long term solutions. Let us understand them briefly one by one.

DNA as Adjuvant: DNA based vaccines are affordable, safe, and are seen to have a good tolerance for patients. The DNA vaccine is preferred over the others due to its low immunogenicity factor. DNA vaccines have autoantigens in them. The self-peptide proteins and certain cytokine genes present in the DNA vaccine promotes in regulating the immune system and might help in treating autoimmune affected patients.

Peptide as adjuvant: The epitopes present in peptide vaccines behaves as a tolerogen. It imitates natural epitopes and eases in treating autoimmune diseases.

T Cell as Adjuvant: T-cell vaccinations are used to target the autoreactive T cell and build an immune response towards it. The autoantigen T cells are initially isolated, inactivated and reinserted as a vaccine. The vaccines are safe, have nil-side effects, and have good tolerance.

T Cell receptor as Adjuvant: The TCR( T cell receptor) has a role in autoimmune diseases. Vaccinations prepared using specific TCR molecule can impel specific immunity regulators to balance and regulate autoreactive T Cells benefiting many autoimmune disease patients.

There is considerable and ongoing research to find a solution for autoimmune disease treatment. Though there might be various factors leading to this medical condition, there is no one solution in treating them. The search for a remedy is still on, and the best is yet to come.